Table VII.
Association between genotypic frequencies of FGFR2 variants and immunohistochemical subtyping of patients with breast cancer
| Allele | A-like, n (freq.) | B-like, n (freq.) | B/HER2-like, n (freq.) | HER2-like, n (freq.) | TNBC, n (freq.) | P-value |
|---|---|---|---|---|---|---|
| rs2981582 | 108 | 439 | 208 | 58 | 139 | 0.525a |
| GG | 36 (0.333) | 133 (0.303) | 54 (0.260) | 16 (0.276) | 37 (0.266) | |
| GA | 42 (0.389) | 209 (0.476) | 105 (0.505) | 24 (0.414) | 66 (0.475) | |
| AA | 30 (0.278) | 97 (0.221) | 49 (0.236) | 18 (0.310) | 36 (0.259) | |
| rs35054928 | 108 | 442 | 210 | 57 | 140 | 0.833a |
| CC/CC | 39 (0.361) | 152 (0.344) | 69 (0.329) | 23 (0.404) | 46 (0.329) | |
| CC/C- | 47 (0.435) | 207 (0.468) | 105 (0.500) | 21 (0.368) | 70 (0.500) | |
| C-/C- | 22 (0.204) | 83 (0.188) | 36 (0.171) | 13 (0.228) | 24 (0.171) | |
| rs2981578 | 108 | 442 | 209 | 58 | 140 | 0.177b |
| CC | 92 (0.852) | 391 (0.885) | 192 (0.919) | 50 (0.862) | 117 (0.836) | |
| CT | 15 (0.139) | 50 (0.113) | 16 (0.077) | 8 (0.138) | 23 (0.164) | |
| TT | 1 (0.009) | 1 (0.002) | 1 (0.005) | 0 | 0 | |
| rs11200014 | 108 | 442 | 210 | 57 | 139 | 0.139a |
| GG | 76 (0.704) | 330 (0.747) | 163 (0.776) | 37 (0.649) | 108 (0.777) | |
| GA | 31 (0.287) | 104 (0.235) | 39 (0.186) | 18 (0.316) | 30 (0.216) | |
| AA | 1 (0.009) | 8 (0.018) | 8 (0.038) | 2 (0.035) | 1 (0.007) |
a
Pearson χ2,
b
Fisher's exact test. A-like, Luminal-A; B-like, Luminal B/HER2-; B/HER2-like, Luminal B/HER2+; TNBC, triple-negative breast cancer.