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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Sci Transl Med. 2023 Apr 19;15(692):eade4790. doi: 10.1126/scitranslmed.ade4790

Fig. 4. H1ssF vaccination decreases the baseline difference in H2 binding and neutralizing antibodies between H2-exposed and H2-naïve individuals.

Fig. 4.

(A and B) Binding antibody concentrations to H2ss assessed by ECLIA (A) and neutralizing IC80 antibody titers against H2N2 assessed by reporter-based microneutralization assay (B) stratified by age group; y.o., years old. (C and D) Binding antibody concentrations to H2ss (C) and neutralizing IC80 antibody titers (D) stratified by expected exposure to H2 influenza; participants born in or after 1969 are considered “H2-naïve,” and those born in or before 1968 are considered “H2-exposed.” Geometric means (GMs) and 95% CI are shown. Fold changes over baseline are indicated at weeks 2, 16, and 18 for (C) and (D). Results of two-sample t tests are shown. In (A) and (B), comparisons were made at each time point for the GMs of the 60- to 70-year-old individuals to the GM of the 18- to 59-year-old individuals combined. In (C) and (D), the GMs of the H2-naïve and H2-exposed individuals were compared. Significance noted applies to each time point under the corresponding black lines. Exact numbers of participant samples analyzed at each time point are listed in table S4.