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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Ann Oncol. 2023 Jan 25;34(4):397–409. doi: 10.1016/j.annonc.2023.01.009

Figure 2. Genomic drivers of poor prognosis breast cancer in the very young.

Figure 2.

(A) Kaplan–Meier plot estimating the rate of freedom from distant recurrence according to age at randomisation in the SOFT combined sequencing cohort (n = 1276). (B) A comparison of genomic driver alteration frequencies of patients in the SOFT combined sequencing cohort (n = 1276) aged <40 years at randomisation with those of patients aged ≥40 years at randomisation. The dotted line provides demonstration of the plot points that represent equal frequencies between the groups. Points in burgundy demonstrated significantly different frequencies after adjustment for multiple testing using the false discovery method. (C) A comparison of the frequencies of copy number-altered subgroups according to patients’ age at randomisation in the SOFT combined sequencing cohort (n = 1276).

CI, confidence interval; HR, hazard ratio; SOFT, Suppression of Ovarian Function Trial.