Figure 3.

Systemic bleeding events (a) and classification of intracranial hemorrhages (b and c) according to ECASS III (b) and HBC (c) according to Neuberger et al. ²⁹ First number refers to bleeding events in patients with active malignancy, while the latter indicates bleeding events in patients in the control group. The percentages in brackets indicate numbers in relation to the total number of the respective group (n = 79 for the active malignancy group and n = 937 for the control group). All bleeding events were adjudicated for their relatedness to stroke treatment. Type 1 (HBC): Hemorrhagic transformation of infarcted tissue; Type 1a (HBC) HI1 (hemorrhagic infarction) (ECASS III): Scattered small petechia, no mass effect; Type 1b (HBC)/HI2 (ECASS III): Confluent petechia, no mass effect; Type 1c (HBC)/PH1 (parenchymal hemorrhage) (ECASS III): Hematoma within infarcted tissue, occupying <30%, no substantive mass effect; Type 2 (HBC)/PH2 (ECASS III): Hematoma occupying >30% or more of the infarcted tissue, with obvious mass effect; Type 3 (HBC): Intracranial hemorrhage outside the infarcted brain tissue or intracranial-extracerebral hemorrhage; Type 3a (HBC): Parenchymal hematoma remote from infarcted brain tissue; Type 3b (HBC): Intraventricular hemorrhage; Type 3c (HBC): Subarachnoid hemorrhage; Type 3d (HBC): Subdural hemorrhage.

AICH, asymptomatic intracranial hemorrhage; ECASS, European Cooperative Acute Stroke Study; HBC, Heidelberg Bleeding Classification; SICH, symptomatic intracranial hemorrhage.