Table 3.
Outcome.
| Outcome | AM | C | OR (95% CI) |
|---|---|---|---|
| Primary safety endpoint | |||
| Major bleeding event* | 4 (5.0) | 46 (4.9) | 1.03 (0.36–2.94) |
| Secondary safety endpoint | |||
| SICH_ECASS* | 4 (5.1) | 40 (4.3) | 1.67 (0.69–4.04) |
| SICH_HBC* | 4 (5.1) | 46 (4.9) | 1.20 (0.46–3.10) |
| Systemic bleeding* | 0 (0) | 6 (0.6) | n.a. |
| Mortality | 25 (31.6) | 153 (16.3) | 2.37 (1.43–3.93) |
| Prolonged length of hospital stay | 8 (10.1) | 33 (3.5) | 3.09 (1.37–6.93) |
| Primary efficacy endpoint | |||
| NI 20% or more | 42 (53.2) | 582 (62.1) | 0.69 (0.44–1.10) |
| NI 30% or more | 40 (50.6) | 539 (57.5) | 0.76 (0.48–1.20) |
| Secondary efficacy endpoint | |||
| NIHSS decrease 4 or more | 30 (38.0) | 375 (40.0) | 0.92 (0.57–1.47) |
| NIHSS decrease 8 or more | 17 (21.5) | 192 (20.5) | 1.06 (0.61–1.86) |
Data are n (%). AM: n = 79; C: n = 937. Logistic regression was performed to compare the occurrence of each endpoint in the active malignancy group with the control group. Results are presented as OR and 95% CI.
*
Stroke treatment related.
AM, active malignancy group; C, control group; CI, confidence interval; n.a., not applicable; NI, neurological improvement during hospital stay; NIHSS, National Institute of Health Stroke Scale; OR, odds ratio; SICH_ECASS, symptomatic intracranial hemorrhage according to ECASS III Classification; SICH_HBC, symptomatic intracranial hemorrhage according to Heidelberg Bleeding Classification.