TABLE 6.

Overview of main findings/interactions across the discrete study measures.

	Main findings in non‐CNS cancer survivors compared to healthy controls	Summary of interactions in non‐CNS cancer survivors between main findings
		FA superior cerebellar peduncle	Chronic symptomatology (VHNSS, GSS, neurotoxicity)	BRIEF neurocognitive functioning (↑ BRIEF scores = ↑ impairment)
Centralized inflammation caudate	↑	X	X	X
Centralized inflammation temporal	↑	X	+ Corr w/: VHNSS; neurotoxicity	X
Centralized inflammation occipital	↑	X	X	− Corr w/: emotion control
Centralized inflammation CSF 3rd ventricle	X	X	X	X
Centralized inflammation CSF 4th ventricle	↓	X	+ Corr w/: sleep disturbance	+ Corr w/: shift
Peripheral pro‐inflammatory cytokines	X	X
Peripheral anti‐inflammatory cytokines	X	X
Peripheral blood C‐Reactive protein	X	−Corr (↓FA = ↑CRP)
White matter FA superior cerebellar peduncle	↓		−Corr w/: VHNSS; GSS; neurotoxicity	X
White matter FA all other ROIs	X
MRI right hemisphere precentral cortical thickness	↓	X	X	X

Note: centralized inflammation = [¹¹C]‐PBR28 SUVR data; peripheral cytokines = blood serum assay data.

Abbreviations: CSF, cerebrospinal fluid; FA, fractional anisotropy from DTI data; GSS, VHNSS General Symptom Survey; VHNSS, Vanderbilt Head and Neck Symptom Survey Version 2.0 total score.