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. 2023 Oct 23;8(20):e162468. doi: 10.1172/jci.insight.162468

Figure 2. Cacna1dIle772Met/+ mice show higher mortality and gain less weight than WT mice.

Figure 2

(A) Kaplan-Meier curve showing survival probability of Cacna1dIle772Met/+ (Het, orange) and WT (blue) mice relative to the number of mice weaned at 21 days. The 95% CI is plotted in a lighter shade around the mean. Mortality is higher in Cacna1dIle772Met/+ than in WT mice from weaning to approximately 100 days of age (log rank test; nWT = 103, nHet = 114; P < 0.005; χ2= 24.39, df = 1). (B) Body weight determined during the SHIRPA assessment prior to behavioral phenotyping experiments (age 13–18 weeks). Cacna1dIle772Met/+ mice are lighter than WT littermates regardless of sex (Mann-Whitney U; nWT, female = 26, nHet, female = 18, P = 0.0004, U = 329.5; nWT, male = 22, nHet, male = 20, P = 6.2×10–5, U = 333). (C) Body length measured during the SHIRPA assessment show that Cacna1dIle772Met/+ mice are shorter than WT littermates regardless of sex (Mann-Whitney U; nWT, female = 22, nHet, female = 17, P = 7.0×10–5, U = 56; nWT, male = 18, nHet, male = 17, P = 2.3×10–5, U = 33). ***P < 0.001.