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. 2023 Oct 23;8(20):e162468. doi: 10.1172/jci.insight.162468

Figure 6. Cacna1dIle772Met/+ mice show motor abnormalities as well as deficits in nest construction.

Figure 6

(A) WT mice stay significantly longer on the rotating rod in rotarod experiments than Cacna1dIle772Met/+ (Het) mice (Mann-Whitney U; nWT = 19, nHet = 19, P = 3.48 × 10–12, U = 2852.5). (B) The total distance covered by Het mice in 10 minutes in the open-field experiment is significantly higher than for WT as a sign of hyperlocomotion (2-tailed t test; nWT = 19, nHet = 19, P = 2.6 × 10–7, t = -6.32). (C) The percentage of the open-field observation time spent in the center of the box is not different between genotypes (Mann-Whitney U; nWT = 19, nHet = 19, P = 0.08, U = 119). (D) Het mice are largely unable to build well-formed nests over 18 hours, as indicated by the lower nest scores (Mann-Whitney U; nWT = 19, nHet = 19, P = 0.0006, U = 281.5). ***P < 0.001.