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. 2023 Oct 23;8(20):e162468. doi: 10.1172/jci.insight.162468

Figure 7. Cacna1dIle772Met/+ mice show hyperlocomotion in response to changes in ambient light but are unable to maintain a hanging position at the top of the cage.

Figure 7

(A–C) Course of 3 groups of home-cage behaviors over time for 24 hours (see Supplemental Figure 5 for all other groups). Cacna1dIle772Met/+ mice show hyperlocomotion as indicated by longer distances traveled (A; likelihood ratio test of linear mixed models; nWT = 19, nHet = 17; Padj = 0.02, z = 0.085) together with increased periods spent moving around (B; likelihood ratio test of linear mixed models; nWT = 19, nHet = 17; Padj = 0.02, z = 0.00208). Hanging from the lid of the cage is significantly reduced in Cacna1dIle772Met/+ mice compared with WT (C; likelihood ratio test of linear mixed models; nWT = 19, nHet = 17; Padj = 0.04, z = 2.631). For all statistical models, genotype was used as fixed and recording as well as time as random factors. All P values are adjusted for 10 comparisons (including the remaining behaviors shown in Supplemental Figure 5) using the FDR method. Data are shown as mean ± 95% CI.