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. 2023 Oct 23;8(20):e173144. doi: 10.1172/jci.insight.173144

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© 2023 Yang et al.

This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kidneys were harvested from PTEC DN RAR mice 3 days after bilateral IRI-AKI. (A and B) F4/80^hi cells (kidney-resident macrophages). (A) F4/80^hi cells as the percentage of gated CD11B⁺CD45⁺Ly6G^– cells. (B) CD11B and F4/80 expression charts in PEPCK Cre⁺ and Cre^– mice after IRI-AKI (percentage in gated area indicated). (C–F) Ly6C^hi cells (inflammatory monocyte/macrophages). (C and E) F4/80^– (infiltrating monocytes) Ly6C^hi cells and F4/80^int (BM-derived macrophages) Ly6C^hi cells, as the percentage of gated F4/80^– and F4/80^int cells, respectively. (D and F) CD11B and Ly6C expression charts. (G and H) CD206/mannose receptor expression (an M2 activated macrophage marker). (G) CD206⁺ cells as the percentage of gated F4/80^hi cells. (H) CD11B and CD206 expression charts. A, C, E, and G used 1-way ANOVA, with P < 0.05 considered significant; q values shown for between-group comparisons corrected for repeated testing.