Figure 2.

Hamster body weight change and SARS-CoV-2 virus replication in the lungs and nasal washes. (A) Percentage of hamster body weight change on the day of sacrifice (day 60, day 4 post-challenge) normalized to body weight on the day of SARS-CoV-2 infection (day 56). Data are expressed as means ± standard deviation. Statistical significance between groups was calculated using an ordinary one-way ANOVA followed by Tukey’s multiple comparison test (***p<0.0002, ****p<0.0001). (B) SARS-CoV-2 sgmRNA levels in the nasal washes (left panel) and lungs (right panel) of MVA-S(3P)-vaccinated hamsters on day 4 post-SARS-CoV-2 infection. Data were expressed as copies per ml of nasal wash or per mg of lung tissue. Data presented as means ± SEM. The dotted line indicates the limit of detection. Statistical significance between groups was calculated using an ordinary one-way ANOVA of transformed data followed by Tukey’s multiple comparison tests (**p<0.002, ***p<0.0002, ****p<0.0001). (C) SARS-CoV-2 infectious particles in the lungs of MVA-S(3P)-vaccinated hamsters on day 4 post-SARS-CoV-2 infection. Data were expressed as TCID₅₀ per mg lung tissue. The dotted line indicates the limit of detection. Data presented as means ± SEM. Statistical significance between groups was calculated using an ordinary one-way ANOVA of transformed data followed by Tukey’s multiple comparison test (****p<0.0001).