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. 2023 Oct 20;19(10):e1011577. doi: 10.1371/journal.pcbi.1011577

Fig 1. Example of AIMS encoding for the analysis of TCR-peptide interactions.

Fig 1

(A) Rendering of a specific TCR-pMHC interaction (PDB ID: 1OGA) with TCRα shown in blue, TCRβ in orange, MHC in white. (B) Inset shows a zoom in on this TCR-peptide interface, with the MHC now translucent. Representative AIMS encoding of the single TCR CDR3β sequence (C, central-encoding) or the peptide sequence (D, bulge-encoding) in panel A. Below these single encodings are examples of full TCR repertoire (C) or immunopeptidome (D) AIMS-encoded matrices. Each amino acid in the structures, the single encoded sequences, and the matrices is represented by a unique color.