Table 1. Effect of Safr and Cands on the levels of 5-hydroxytryptamine (5-HT, μg/g tissue), 5-hydroxyindoleacetic acid (5-HIAA, μg/g tissue), norepinephrine (NE, μg/g tissue) and dopamine (DA, μg/g tissue) in striatum of 3-NP-treated rats.
| Parameter | Control groups | Experimental groups | Effect of treatment | |||||
|---|---|---|---|---|---|---|---|---|
| PO | CMC | Safr | Cands | 3-NP | Safr + 3-NP | Cands + 3-NP | ||
| 5-HT | 0.34±0.03B | 0.35±0.03B | 0.35±0.03B | 0.36 ±0.04B | 0.21 ±0.02A | 0.34±0.03B | 0.34±0 .02B | F6,63 = 3.29, P<0.007 |
| 5-HIAA | 0.21±0.01B | 0.24±0.01B | 0.25±0.03B | 0.20±0.02B | 0.051±0.01A | 0.20±0.02B | 0.21±0.02B | F6,63 = 15.59, P<0.000 |
| NE | 0.86±0.04B | 0.87±0.06B | 0.89±0.08B | 0.89±0.07B | 0.50±0.04A | 0.85±0.05B | 0.85± 0.05B | F6,63 = 5.87, P<0.000 |
| DA | 0.87±0.09B | 0.90±0.05B | 0.86±0.04B | 0.87±0.08B | 0.44±0.04A | 0.82±0.08B | 0.79± 0.07B | F6,63 = 6.04, P<0.000 |
In the same row, values marked with the same superscript CAPITAL letters are insignificantly different (P>0.05), whereas those with different ones are significantly different (P<0.05). P<0.000: Represents significant effect of treatment.
Cands: Candesartan, CMC: Carboxymethyl cellulose, PO: Paraffin oil. Safr: Safranal, and 3-NP, 3-nitropropionic acid.
Data is displayed as mean ± standard error (SE).