Table 4. Effect of Safr and Cands on the levels of complex I (U/mg protein), complex II (U/mg protein), complex IV (U/mg protein), caspase-3 (Casp-3, μg/mg protein), Fas ligand (FasL, μg/mg protein) and inducible nitric oxide synthase (iNOS, μg/mg protein) in striatum of 3-NP-treated rats.
| Parameter | Control groups | Experimental groups | Effect of treatment | |||||
|---|---|---|---|---|---|---|---|---|
| PO | CMC | Safr | Cands | 3-NP | Safr + 3-NP | Cands + 3-NP | ||
| Complex I | 80.82 ±2.91C | 80.82±2.91C | 80.78±2.58C | 81.47±2.27C | 24.14±1.15A | 66.09±1.09B | 62.58± 1.00B | F6,63 = 95.03, P<0.000 |
| Complex II | 49 ±.1.63C | 49±1.63C | 49.31±0.78C | 49.15±2.04C | 16.92±0.85A | 38.06±0.76B | 32.78± 1.06B | F6,63 = 85.52, P<0.000 |
| Complex IV | 26.88 ±.95C | 26.88±0.95C | 27.06±1.15C | 26.93±2.27C | 11.78±0.54A | 19.99±0.39B | 18.03± 1.89B | F6,63 = 23.85, P<0.000 |
| Casp-3 | 1.00 ±0.00A | 1.01±0.01A | 1.00±0.00A | 1.01±0.01A | 5.80±0.48C | 2.06±0.56B | 1.97±0.44B | F6,63 = 174.59, P<0.000 |
| FasL | 1.01 ±0.00A | 1.01±0.00A | 1.00±0.01A | 1.01±0.02A | 5.17±0.18C | 2.03±0.04B | 2.18±0.05B | F6,63 = 455.51, P<0.000 |
| iNOS | 1.01±0.00A | 1.01±0.00A | 1.04±0.01A | 1.00±0.00A | 6.38±0.11C | 2.48±0.09B | 2.70±0.04B | F6,63 = 1230.8, P<0.000 |
In the same row, values marked with the same superscript CAPITAL letters are insignificantly different (P>0.05), whereas those with different ones are significantly different (P<0.05).
P<0.000: Represents significant effect of treatment.
Cands: Candesartan, CMC: Carboxymethyl cellulose, PO: Paraffin oil. Safr: Safranal, and 3-NP, 3-nitropropionic acid.
Data is displayed as mean ± standard error (SE).