Table 5. Effect of Safr and Cands on the levels of % DNA damage in tail (arbitrary unit), tail length (TM, Mm) and tail moment (TM, arbitrary unit) in striatum of 3-NP-treated rats.
| Parameter | Control groups | Experimental groups | Effect of treatment | |||||
|---|---|---|---|---|---|---|---|---|
| PO | CMC | Safr | Cands | 3-NP | Safr + 3-NP | Cands + 3-NP | ||
| %DNA | 2.06±0.11A | 2.09±0.09A | 2.17±0.09A | 2.27±0.06A | 4.11±0.09C | 3.30±0.03B | 3.55± 0.03B | F6,63 = 116.6, P<0.000 |
| TL | 2.07±0.06A | 1.99±0.03A | 2.21±0.04A | 2.19±0.17A | 3.98±0.06C | 3.03±0.09B | 3.19± 0.18B | F6,63 = 49.43, P<0.000 |
| TM | 4.15±0.14A | 4.22±0.22A | 4.78±0.13A | 4.54±0.06A | 16.24±0.37D | 9.86±0.18B | 11.89± 0.52C | F6,63 = 301.9, P<0.000 |
In the same row, values marked with the same superscript CAPITAL letters are insignificantly different (P>0.05), whereas those with different ones are significantly different (P<0.05).
P<0.000: Represents significant effect of treatment.
Cands: Candesartan, CMC: Carboxymethyl cellulose, PO: Paraffin oil. Safr: Safranal, and 3-NP, 3-nitropropionic acid.
Data is displayed as mean ± standard error (SE).