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. 2023 Oct 18;14:1261204. doi: 10.3389/fphys.2023.1261204

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Copyright © 2023 Song, Zhang, Wang, Wu, Xiong, Shen, Lin, Xiao and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peridroplet mitochondria (PDM) in white adipocytes and brown adipocytes. Mitochondria are attached to lipid droplets in adipocytes, forming what is known as peridroplet mitochondria (PDM). This attachment is facilitated by proteins such as PLIN5 and DGAT2, as well as other unknown mechanisms. Compared to CM, PDM has a higher capacity for pyruvate oxidation, electron transfer, and ATP synthetic, but lower capacity for β oxidation and dynamic activity. However, PDM may play a key role in expanding lipid droplets.