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. 2023 Oct 18;14:1261204. doi: 10.3389/fphys.2023.1261204

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Copyright © 2023 Song, Zhang, Wang, Wu, Xiong, Shen, Lin, Xiao and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of mitochondria-associated endoplasmic reticulum membrane (MAM) in adipocytes. MAM is a site of connection between the mitochondria and the endoplasmic reticulum, facilitated by thousands of proteins, such as Seipin and PERK. In mice, deletion of Seipin induces diabetes, hepatic steatosis, and damaged lipid metabolism. MAM plays a key role in maintaining the homeostasis of calcium in the mitochondria. High-fat diets and obesity can lead to an excessive MAM and overloaded calcium, causing mitochondria to release apoptotic factors into the cytoplasm. This is due to excess the accumulation of calcium in the mitochondria, which ultimately leads to cell apoptosis.