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. 2023 Oct 18;14:1261204. doi: 10.3389/fphys.2023.1261204

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Copyright © 2023 Song, Zhang, Wang, Wu, Xiong, Shen, Lin, Xiao and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adipocyte-derived mitochondria transferring. In adipose tissue, damaged mitochondria in adipocytes are transferred to macrophages via vesciles. However, this process is inhibited in obesity, leading to the accumulation of damaged mitochondria in adipocytes. The process of macrophages taking in damaged mitochondria is associated with the HS synthetic pathway. Knock out Ext1, which encodes HS, inhibits the ability of macrophages to take in damaged mitochondria. Long-chain fatty acids in a high-fat diet inhibits the transfer of damaged mitochondria into macrophages and promote the transfer of damaged mitochondria into other organs through circulation. It is currently unknown whether adipocytes can uptake in healthy mitochondria to enhance metabolism.