Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 16;39(10-12):708–727. doi: 10.1089/ars.2022.0209

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Sergio Rius-Pérez et al., 2023; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 2. — Regulation of necroptosis by mtROS. Increased aerobic respiration, mitochondrial translocation of NOX4, and p53-dependent SRX and PRX3 downregulation increased mtROS. Increased mtROS cause mitochondrial translocation of p53 and RIP1K phosphorylation. Phosphorylated RIPK1 recruits and phosphorylates RIPK3 into the necrosome. Phosphorylated RIPK3 then phosphorylates MLKL, triggering the formation of MLKL oligomers that translocate and destabilize the plasma membrane. MLKL, pseudokinase mixed-lineage kinase domain–like; mtROS, mitochondrial reactive oxygen species; NOX, NADPH oxidases; PRX3, peroxiredoxin 3; RIPK1/3, receptor-interacting protein kinases 1 and 3; SRX, sulfiredoxin.