Fig. 6. Comparison of geometric mean of IET2 sensitivity to demyelinating disease pathology.

From left to right, columns show sagittal, coronal, and axial orientation views, respectively, for a subject living with relapsing-remitting multiple sclerosis (male, age 60 years, expanded disability status scale of 2.0, and disease duration of 12 years). (A) Full slices of a FLAIR anatomical image are shown with red boxes highlighting a region centered around a particularly large FLAIR hyperintense lesion. Close-up views of this region are shown in (B) for IET2 from our proposed CALIPR MWI approach, in (C) for FLAIR, and in (D) for IET2 from a commonly used GRASE MWI approach. All images and maps were aligned in the subject’s T₁-weighted image space to ensure that the exact same region could be compared.