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. 2023 Sep 25;623(7985):139–148. doi: 10.1038/s41586-023-06651-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (A-B) Violin plots of myeloid peripheral blood mononuclear populations (PBMCs) plotted by group as percentages of respective parent populations (gating schemes detailed in Extended Data Fig. 10). (B, right) Coefficients from linear model are shown. Model predictors are indicated on x-axis. Significant predictors (p ≤ 0.05) are plotted in purple. Detailed model results are reported in Extended Data Table 4. (C) Violin plots of B lymphocyte subsets from PBMCs plotted as percentages of respective parent populations (gating schemes detailed in Extended Data Fig. 10). (D,E) Violin plots of various CD4⁺ (top row) and CD8⁺ (bottom row) populations. (F) Violin plots of IL-4 and IL-6 double-positive CD4⁺ (left) and CD8⁺ (right) T cells plotted as percentages of total CD4⁺ or CD8⁺ T cells. (G) A PERMANOVA test of the association between all cell populations shown and participant age, sex, LC status, and body mass index (BMI). For all violin plots (A–F), significance was assessed using Kruskal-Wallis corrected for multiple comparisons using Bonferroni-Holm. Each dot represents a single patient (n = 40 HC, 33 CC, 99 LC). Central bars indicate the median value of each group. Only significant differences between group medians are shown.