Table 1.
Summary of PDX tumours. n.d., no data.
| Tumour | UICC | KRAS | Response to cetuximab and trametinib | Response to trametinib | ||
|---|---|---|---|---|---|---|
| Day 28 | Day 59 | Day 28 | Day 59 | |||
| BoC51 | I | G12D | PD | PD | ||
| BoC64 | IV | G12D | PD | |||
| BoC109 | IIIC | G13D | PD | |||
| BoC117 | IVA | G12D | PD | PD | PD | PD |
| BoC122 | IIIB | G12D | PD | PD | PD | PD |
| BoC2 | IV | G12D | SD | SD | PD | PD |
| BoC19 | IIA | A146T | SD | |||
| BoC56 | IIA | G12C | SD | SD | ||
| BoC78 | IIA | G12D | SD | SD | ||
| BoC136 | n.d. | G12V | SD | SD | PD | PD |
| BoC9 | IV | G12D | PR | PR | ||
| BoC14 | IIA | A146T | PR | PR | ||
| BoC46 | IIA | G13D | PR | |||
| BoC47 | IIIB | G12D | PR | PR | SD | SR |
| BoC80 | IB | G12V | PR | PR | ||
| BoC105 | IIIB | G12V | PR | PR | SD | SR |
| BoC130 | IIIC | G12D | PR | PR | ||
| BoC137 | IVB | G12D | PR | PR | PD | PD |
| BoC147 | IIIB | G12A | PR | PR | SD | SD |