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. 2023 Aug 8;17(11):2472–2490. doi: 10.1002/1878-0261.13499

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© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — The driver gene set identified by TCGA‐19‐1390. (A) The dysfunctional cancer hallmarks in TCGA‐19‐1390. (B) The correlation between dysfunctional scores and enrichment scores driven by driver genes. (C) The cancer hallmarks were significantly driven by the driver genes. P was calculated by R function cor.test(). (D) The cumulative contributions of driver genes on the dysfunction of cancer hallmarks. (E) The dysfunction of cancer hallmarks driven by the driver genes including PARP1, PDGFRA, DAB1, and CREBL2. (F) The signature E2F_TARGETS cooperatively driven by PARP1, PDGFRA, and CREBL2. (G) The signature G2M_CHECKPOIN cooperatively driven by PARP1 and PDGFRA.