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. 2023 Aug 8;17(11):2472–2490. doi: 10.1002/1878-0261.13499

Fig. 7.

Fig. 7

The knockdown of MCM4 in GBM cancer cells. (A) Endogenous MCM4 expression in GBM cell A172, U87MG, U118MG, and U251. (B) SiRNAs could efficiently silence MCM4 expression. (C) The CCK‐8 assay detected the effect of knockdown of MCM4 on cell proliferation of U118MG and U251. (D) Transwell assay detected the effect of knock‐down of MCM4 on cell invasion of U118MG and U251. Scale bars, 40 μm. Magnification ×200. (E) Cell scratch assay detected the effect of knockdown of MCM4 on cell migration of U118MG and U251. Scale bars, 200 μm. Magnification ×200. (F) Clone formation assay detected the effect of knockdown of MCM4 on cell formation abilities of U118MG and U251. NC, normal control; error bars represent standard deviation (SD). Results were summarized as mean ± SD of three independent experiments (*P < 0.05; **P < 0.01; ***P < 0.001, independent Student's t test).