Table 1.

Key questions.

Questions
BAP1 phenotypic spectrum
What cancers can be considered part of the BAP1-tumour predisposition syndrome?
Are there specific histological subtypes of associated cancers?
Are there other cancers whose association is not yet established?
BAP1 cancer risk
What are the lifetime cancer risks for BAP1 carriers, overall and for specific cancers?
Identification of BAP1 carriers
What is the detection rate of BAP1 GPV in patients with a specific cancer?
Who should be offered genetic testing of BAP1?
BAP1 cancer surveillance
Should individuals undergo surveillance for mesothelioma, renal cancer, uveal or cutaneous melanoma or other cancers? If so, what are the recommendations- clinical or research?
BAP1 predictive testing (i.e., testing an unaffected individual for a familial GPV)
What age should predictive testing be recommended?
What surveillance should be offered to those at 50% risk?