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. 2023 Nov 1;13:18848. doi: 10.1038/s41598-023-45870-1

Figure 3.

Figure 3

Effects of LDL versus LPS on IL-1β-secretion from hMDM: IL-1β-secretion from hMDM from 5 subjects after incubation with their own native LDL (0.1–1.2 g/L apoB) over 4 h (A) or with 1.2 g/L LDL over 1–24 h (B) without ATP. Experiments in panel A following removal of priming medium and re-incubation with ATP (3 mmol/L) over 3 h (C), and experiments in panel B following removal of medium and re-incubation with ATP (3 mmol/L) over 3 h (D). LPS (10 ng/mL) was used as a priming control in all experiments. Data was analyzed by non-parametric Friedman test separately for LDL. **for p < 0.01 and ***for p < 0.001 versus baseline.