Table 4.
Partial correlation of plasma apoB with risk factors for type 2 diabetes before and after adjustment for LOG10 fasting WAT IL-1β-secretion induced by the 7-incubation conditions with medium, LDL, LPS and/or ATP, WAT NLRP3 mRNA, WAT IL1B mRNA and WAT pro-IL-1β protein expression, or body composition measures.
| Adjustment for | LOG10 2nd phase GIISIVGTT | LOG10 2nd phase C- peptide secretionIVGTT | LOG10 total C-peptide secretionIVGTT | M/Iclamp | LOG10 plasma IL-1Ra | LOG10 AUC6hrs TG | AUC6hrs apoB48 |
|---|---|---|---|---|---|---|---|
| p values | |||||||
| None | 0.038 | 0.025 | 0.031 | 0.001 | 0.032 | < 0.001 | 0.029 |
| WAT IL-1β (LDL/LDL) | – | 0.024 | 0.029 | 0.006 | – | < 0.001 | 0.042 |
| WAT IL-1β (medium/ATP) | – | – | – | 0.007 | 0.040 | < 0.001 | 0.031 |
| WAT IL-1β (LDL/ATP) | 0.044 | 0.014 | 0.018 | 0.003 | – | < 0.001 | 0.033 |
| WAT IL-1β (LPS/medium) | – | 0.043 | – | 0.004 | – | < 0.001 | – |
| WAT IL-1β (LPS/LDL) | – | – | – | 0.031 | – | 0.002 | – |
| WAT IL-1β (LPS/ATP) | – | – | – | – | – | 0.002 | – |
| WAT NLRP3 mRNA | – | – | – | 0.010 | – | < 0.001 | – |
| WAT IL1B mRNA | – | – | – | 0.004 | – | < 0.001 | 0.036 |
| WAT pro-IL-1β protein | 0.036 | 0.033 | 0.041 | 0.002 | 0.035 | < 0.001 | 0.025 |
| BMI | – | – | – | 0.018 | – | < 0.00 | 0.044 |
| Total fat mass | – | – | – | 0.047 | – | < 0.001 | 0.042 |
| Waist/hip ratio | – | 0.034 | 0.043 | 0.003 | 0.043 | < 0.001 | – |
| Android/gynoid fat ratio | – | – | – | 0.012 | – | < 0.001 | – |
N = 27 females and N = 13 males for WAT mRNA and protein and anthropometric parameters, N = 23 females and N = 11 males for WAT IL-1β-secretion conditions except for LDL/LDL condition where and N = 21 females and N = 10 males for missing data.