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. 2023 Oct 19;17:1295563. doi: 10.3389/fnins.2023.1295563

Table 4.

Application of DNT in nerve regeneration.

Animal species/Sex Decellularized tissue/Implantation site Study period Finding References
Rat/Female Sciatic/Sciatic About 20 days (Not mentioned exactly) Become allografts for the repair of the sciatic nerve Sondell et al. (1998)
Rat/Male Sciatic/Sciatic 84 days The decellularization process averted cell-mediated rejection of the grafts Hudson et al. (2004b)
Rat/Female Sciatic/Sciatic 8 days Bloc chondroitinase treatment of acellular nerve grafts effectively degraded CSPG without compromising the basal lamina scaffold or dislocating its laminin content Krekoski et al. (2001)
Rat& rabbit/Not mentioned Sciatic/Sciatic 8 weeks Muscular atrophy and motor function were recovered partially Jia et al. (2012)
Rat/Female Sciatic/Sciatic 12 weeks The percentage of neurotrophic ulcers was significantly higher in the RSN group than in the SD group Chato-Astrain et al. (2020)
Rat/Not mentioned Sciatic/Sciatic 11 weeks The sciatic nerve action potentials, the thickness of the myelin sheath, the diameter of the axon and the dominated muscle are more rehabilitated than the blank group Wang et al. (2017)
Rat/Male Sciatic/Sciatic 8 weeks nearly all functional and histological assessments performed in a rat defect of the sciatic nerve over an 8-week time course Wachs et al. (2022)
Rat/Female Sciatic/Sciatic 2 months Resulting in the generation of a structure that was almost the same as that of the intact nerve. Ishida et al. (2014)
Rat/Not mentioned Sciatic/Sciatic Not mentioned The optimized protocol is comparable to the Sondell protocol in its ability to remove cellular components and is better at retaining the natural ECM Hudson et al. (2004a)
Rat/Male Sciatic/Sciatic 16 weeks Host nerve tissue distal to the interposed silicone conduit appeared atrophic and translucent, suggesting a general absence of healthy myelinated axons Moore et al. (2011)
Rats/Not mentioned Sciatic/Sciatic 12 weeks The function and response of the thermal motivator of autograft nerves are like normal nerve Kong et al. (2022b)
Rat/Not mentioned dcBECM/dcBECM (PD) 2 weeks Effective in 11 removing the cellular components while keeping the micro- and ultra-structure characterized of the brain architecture and composition of the matrix Lin et al. (2017)
Pig/Not mentioned Sciatic/Sciatic 24 weeks After 18 weeks, displayed statistical differences but at 24 weeks, they were not retained between groups, and Lower self-mutilation in the GFNC group than in others Choi et al. (2018)
Beagle dog/Not mentioned Sciatic/Sciatic 6 months enhance nerve regeneration and functional recovery after repair of long nerve defects Qiu et al. (2020)