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. 2023 Nov 1;14:6993. doi: 10.1038/s41467-023-42837-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Scheme of the location of QSCs, CSCs and ASCs in relation to muscle injury. QSCs, quiescent MuSCs. CSCs, contralateral MuSCs. ASCs, activated MuSCs. b Scheme of the experimental strategy. c Statistical analysis of the number of total MuSCs or tdT⁺ (Gli1⁺) MuSCs per section in TA muscle of uninjured mice and the contralateral TA muscle of injured mice (n = 8). d Left panel: Quantification of the percentage of CSCs from the contralateral TA muscle of injured Gli1-CreERT2; R26-tdT mice at 1 dpi. The yellow histogram represented the percentage of increased MuSCs from the contralateral TA muscle compared with uninjured mice (n = 8). Right panel: Quantification of the percentage of tdT⁺ (Gli1⁺) and tdT⁻ (Gli1⁻) CSCs in increased MuSCs from the contralateral TA muscle. The blue histogram represented the percentage of increased tdT⁻ (Gli1⁻) CSCs. The red histogram represented the percentage of increased tdT⁺ (Gli1⁺) CSCs. dpi, day post injury. e Schematic overview of the participation of Gli1⁺ MuSCs in muscle regeneration. Gli1 marks a distinct population of MuSCs, which serves as sentinel cells to enable rapid response after injury and speed muscle regeneration. Data are presented as mean ± SEM; Statistical significance was determined by two-tailed unpaired Student’s t test (c). All numbers (n) are biologically independent experiments. Source data are provided in the Source Data File.