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. 2023 Oct 13;12(11):e230040. doi: 10.1530/EC-23-0040

Table 1.

Studies about the relationship between sUA and bone published on PubMed in the last 5 years.

No. and Ref. Nation Study design Study population Conclusion
1 (24) China Cross-sectional study Adolescents aged 12–19 years

  1. sUA is positively associated with total BMD.

  2. Association between sUA and total BMD for female adolescents, adolescents aged 16–19 years, showed an inverted U-shaped curve.
2 (25) Iran Cross-sectional study 413 adolescents aged 9–19 years (22 women and 192 men) Higher BMD is correlated with higher UA levels.
3 (18) Qataris Cross-sectional study 2981 healthy adults (36.4 ± 11.1 years old) High levels of sUA are significantly associated with increased BMD (P<0.001).
4 (34) Italy Retrospective study 124 premenopausal women (35 ± 10 years old)
234 postmenopausal women (55 ± 4 years old)		 In estrogen-deficient women, sUA is significantly and positively associated with total hip BMD (P<0.05) and greater trochanter BMD (P<0.05).
5 (26) India Cross-sectional study 310 health checkups (women: 43.5%; men: 56.5%) (47.2 ± 12.2 years old) UA is positively correlated with BMD at all skeletal sites (P<0.05).
6 (35) South Korea Cross-sectional study 6588 healthy males (48.2 ± 10.7 years old) For every 1 mg/dL increase in sUA, lumbar BMD increased by 0.0054 g/cm2 (P = 0.004).
7 (27) China Cross-sectional study 385 males >50 years of age sUA levels are positively correlated with higher BMD and T values in the lumbar spine.
8 (28) China Cross-sectional study 631 men with T2DM (57.3 ± 12.0 years old) sUA is positively correlated with BMD in the lumbar spine (P<0.001), femoral neck (P = 0.002), and total hip (P = 0.001).
9 (19) China Cross-sectional study 3465 people >60 years of age

  1. Higher sUA levels are associated with higher BMD (P<0.05).

  2. Prevalence of OP was 23–26% lower in those with higher sUA levels compared to those with lower sUA levels (P<0.05).
10 (23) China Cross-sectional study 943 males and 4256 postmenopausal females (63.7 ± 4.2 years old) sUA levels are positively associated with femoral neck BMD, and total hip BMD.
11 (33) China Cross-sectional study 390 healthy postmenopausal women aged 47–89 years Lumbar BMD is positively correlated with sUA.
12 (30) China Cross-sectional study 626 males with T2DM (60.66 ± 11.80 years old) sUA levels are positively correlated with BMD in the lumbar spine, femoral neck, and total hip (P< 0.05).