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. Author manuscript; available in PMC: 2023 Nov 2.
Published in final edited form as: J Cardiovasc Transl Res. 2021 Jul 20;15(1):167–178. doi: 10.1007/s12265-021-10153-5

Fig. 5. Intracellular Ca2+ measures in CSM cells.

Fig. 5

Typical Ca2+ tracings show the change in the F340/F380 excitation fluorescence emission ratio from human and swine CSM cells. There are similarities between humans with mild, non-ischemic CAD and lean swine and between humans with severe, ischemic CAD and MetS swine (a). Mild, non-ischemic CAD was defined by a plaque burden below 50%, while severe, ischemic CAD was defined by a plaque burden of over 75%. Both humans and swine with CAD exhibit decreased Ca2+ influx (b), SR Ca2+ store capacity (c), and SERCA function (d). Group data are plotted as mean ± SE with black lines and bars; individual cells are show in blue symbols for humans and red symbols for swine.