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. 2023 Nov 1;221(1):e20231035. doi: 10.1084/jem.20231035

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© 2023 Solomon et al.

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Figure 5. — Remodeling of the MPP4 compartment during inflammation and aging. (A) Experimental scheme. (B–E) Number of neutrophils in blood (B), BM cellularity and absolute number of BM myeloid cells (C), absolute number of BM HSPCs (D), and percentage of CD48⁻ CD62L⁻, CD48⁺ CD62L⁻, and CD48⁺ CD62L⁻ subsets in MPP3 and MPP4 (E) following LPS treatment (day 0 n = 5; day 1 n = 4; day 3 n = 3; day 8 n = 3). (F) Representative FACS plots showing Ki67-RFP expression in MPP4 cells after LPS treatment (n = 2). (G) Absolute number of MPP4 subsets in the BM of young (2 mo) and old (18 mo) mice (n = 10 and 4/group). Right panel indicates the relative proportion of MPP4 subsets in young and old mice. (H) Representative FACS plots of the phenotypic analyses gate of LSK cells from young and old mice. Graphs indicate mean ± SD. Two-way ANOVA with Sidak’s post hoc test: *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.005; ****, P ≤ 0.0001.