Table 1.

General characteristics of the included studies.

References	Region	Design	Model	Outcome	STROBE score	Quality*
Shikata et al. (2019)	North America	In vivo longitudinal interventional	Animal	Growth of UIA	17/22	High
Li et al. (2020)	Asia	Case–control observational (a) and in vivo (b)	Human (a) and animal (b)	Growth of UIA and aSAH	18/22	High
Sun et al. (2022)	Asia	Case–control observational	Human	Symptomatic progression of UIA	19/22	Very high
Kawabata et al. (2022)	Asia	Case–control observational	Human	aSAH	20/22	Very high

The STROBE score refers to the number of STROBE statement items that were addressed in a given study. Quality^*: low if the STROBE score was < 11; moderate if the STROBE score was 11–14; high if the STROBE score was 15–18; very high if the STROBE score was 19–22. aSAH, aneurysmal subarachnoid hemorrhage; STROBE, Strengthening the Reporting of Observational Studies in Epidemiology; UIA, unruptured intracranial aneurysm.