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. 2023 Sep 22;42(21):e113448. doi: 10.15252/embj.2023113448

Figure 7. The BCL11B‐NuRD complex mediates mitochondrial dynamics to promote the reprogramming of T cells to ITNKs via epigenetic remodeling.

Figure 7

Schematic representation of the mechanism by which BCL11B and the NuRD complex inhibit the expression of OPA1 and NK‐cell‐associated genes in human T cells (left). OPA1‐mediated mitochondrial fusion regulated by the BCL11B‐NuRD complex promotes the reprogramming from T cells into ITNKs by regulating H3K27Ac modification (right). The graphics were created with BioRender.com.