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Schematic of engineered live bacterial therapeutics. An LBT can simultaneously sense surrounding input signals, and process the signals using elaborate Boolean logic gates, which are relayed to guide response outpuslt. By tethering the output signals with appropriate actuator genes, an LBT can execute user-programmed functionalities such as genetic memory (with base editor; BE), and therapeutic delivery, in vivo. Abbreviations–TEA: terminal electron acceptor, BE: base editor.
