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. 2023 Oct 16;19(16):5218–5232. doi: 10.7150/ijbs.85656

Figure 7.

Figure 7

CENPA expression is positively correlated with YY1 expression in human HCC tissues. (A) YY1 mRNA expression in HCC tissues and adjacent non-tumor tissues of paired patients in Tongji cohort. (B) YY1 protein level in nontumor and HCC tissues from Tongji cohort as determined by western blotting, the band intensity was calculated by Image J software (P<0.001). GAPDH was used as loading control. (C) The correlation analysis of the CENPA and YY1 protein levels in Tongji cohort as determined by qRT-PCR. (D) Representative IHC staining images of the YY1 expression in HCC and adjacent tissues in Tongji HCC TMA cohort and a statistical evaluation of the staining intensity (P<0.0001). (E) The IHC scores demonstrated a high correlation between CENPA and YY1 staining in Tongji HCC TMA cohort (chi-square test). (F) Kaplan-Meier curves of the OS and RFS rates among groups with differential CENPA/YY1 expression in TCGA database. (G) A schematic model of the mechanism by which CENPA promotes HCC progression. The statistical significance was determined by Student's two-tailed t test. *P < 0.05; **P < 0.01; ***P < 0.001.