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. 2023 Oct 16;19(16):5233–5244. doi: 10.7150/ijbs.85204

Figure 1.

Figure 1

Apigenin attenuates Dox-mediated myocardial injury. Mice were treated with Dox (15 mg/kg) with or without oral apigenin co-administration (25 mg/kg) for 4 weeks. (A-C) Serum was isolated from mice and the levels of TnT, BNP, and CK-MB were measured through ELISA. (D) Sirius Red staining was used to observe histological alterations in heart tissue. (E, F) GR-1 immunofluorescence was used to evaluate neutrophil infiltration in the myocardium. (G-H) The transcription of IL-6 and MMP9 in heart tissues was assessed by RT-PCR. *p<0.05.