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. 2023 Oct 16;19(16):5233–5244. doi: 10.7150/ijbs.85204

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Sirt1 knockdown abolishes the cardioprotective effects of apigenin in mice with Dox-induced cardiomyopathy. Wild-type (WT) and Sirt1 knockout (KO) mice were treated with Dox (15 mg/kg) with or without concomitant oral apigenin (25 mg/kg) administration for 4 weeks. (A-C) Serum levels of TnT, BNP, and CK-MB were measured by ELISA. (D) Sirius Red staining was used to observe histological alterations in heart tissue. (E, F) GR-1 immunofluorescence was used to assess neutrophil infiltration in the myocardium. (G-H) RT-PCR was used to analyze the transcription of IL-6, MCP1, and MMP9 in heart tissues. *p<0.05.