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. 2023 Oct 2;19(16):5160–5173. doi: 10.7150/ijbs.86207

Figure 2.

Figure 2

AQP3 deficiency blocks rosacea development. (A) Schematic diagram of intradermal injection of LL37 in mice (Aqp3-/- and WT mice). Mice were sacrificed on day 2 to conduct subsequent experiments. The mouse experiments were repeated for three times, and 5-8 mice were included in each group for each time. The results of a representative mouse experiment were displayed. (B) The back skins of WT and Aqp3-/- mice were intradermally injected with LL37 (n=5/group). Images were taken 48 hr after the first LL37 injection. Scale bar: 2 mm. (C and D) The severity of the rosacea-like phenotype was evaluated on account of the redness area (C) and score (D). (E) HE staining of lesional skin sections from WT and Aqp3-/- mice injected with LL37 (n=5/group). Scale bar: 50 μm. (F) Quantitative result of HE staining for dermal cellular infiltrates is shown. Data represent the mean ± SEM. (G) The mRNA expression levels of Tlr2, Il-1b, Il-6, Mmp9, and Vegf in skin lesions (n=5/group). Data represent the mean ± SEM. One-way ANOVA with Bonferroni's post hoc test was used.