Figure 4.

Mechanism of ferroptosis in RA synovium Lipid peroxides as well as iron deposition can be seen in RA synovium. In addition, proinflammatory factors secreted by immune cells and FLS in RA synovium promote oxidative stress, which in turn further exacerbates the inflammatory response, and through this vicious circle, ferroptosis and synovial inflammation are promoted, FLS, fibroblast-like synoviocyte; IL-6, interleukin 6; RNS, reactive nitrogen species; ROS, reactive oxygen species; TNF, tumor necrosis factor; RANKL, Receptor Activator for Nuclear Factor-kB Ligand; MMPs, matrix metalloproteinases.