Table 3. ADMET Profile of 24.
| absorption | intestinal absorption | yes |
|---|---|---|
| absorption | skin permeability | yes |
| distribution | BBB permeability | yes |
| distribution | CNS permeability | yes |
| metabolism | CYP2D6 substrate | no |
| metabolism | CYP3A4 substrate | yes |
| metabolism | CYP1A2 inhibitor | yes |
| metabolism | CYP2C19 inhibitor | yes |
| metabolism | CYP2C9 inhibitor | yes |
| metabolism | CYP2D6 inhibitor | yes |
| metabolism | CYP3A4 inhibitor | no |
| excretion | renal OCT2 substrate | yes |
| toxicity | AMES toxicity | yes |
| Toxicity | Hepatotoxicity | Yes |
| Toxicity | Skin Sensitization | No |