Table 3.
Multivariate analysis of the association between HA burden and CAA burden.
| Variables | Lobar CMBs ≥ 5* | High CAA score* | ||
|---|---|---|---|---|
| Adjusted OR (95% CI) | p | Adjusted OR (95% CI) | p | |
| The presence of lacune, n (%) | 3.909 (1.587–9.625) | 0.003 | 3.297 (1.496–7.267) | 0.003 |
| The presence of deep CMB, n (%) | 5.138 (0.955–27.631) | 0.057 | 4.493 (1.110–18.182) | 0.035 |
| Deep CMB ≥ 5, n (%) | 4.600 (1.811–11.687) | 0.001 | 3.019 (1.285–7.094) | 0.011 |
| The number of deep CMBs, median (IQR) | 1.057 (1.002–1.116) | 0.043 | 1.052 (0.997–1.110) | 0.066 |
| Periventricular WMH scored 3, n (%) | 3.002 (1.258–7.160) | 0.013 | 5.306 (2.314–12.171) | <0.001 |
| Deep WMH scored ≥2, n (%) | 5.075 (1.859–13.857) | 0.002 | 5.595 (2.324–13.470) | <0.001 |
| The presence of WMH, n (%) | 5.425 (1.911–15.398) | 0.001 | 8.840 (3.355–23.291) | <0.001 |
| HA score, median (IQR) | 2.317 (1.483–3.621) | <0.001 | 2.241 (1.504–3.338) | <0.001 |
HA, Hypertensive angiopathy; CAA, Cerebral amyloid angiopathy; CMB, Cerebral microbleed; WMH, White matter hyperintensities; and IQR, Interquartile range. *Multivariate binary regression was used. The presence of lobar CMBs ≥5 (vs. lobar CMBs <5) or high CAA score (vs. absence of high CAA score) was entered as dependent variable. Each of the HA related CSVD makers was entered into the regression analysis separately, by adjusting for age, male sex, hypertension, diabetes mellitus, hyperlipidemia, smoking, alcohol, and ICH etiology. The bold values in table represent that they were less than 0.05.