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. 2023 Oct 19;10:1044402. doi: 10.3389/fmed.2023.1044402

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Copyright © 2023 Wang, Shan, Shi and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Sets Variation Analysis (GSVA) of ANG-related inflammatory activities in CGGA301 dataset. (A) Gene heatmap of different inflammatory activities arranged by ANG expression in CGGA301 lower-grade glioma. (B) Gene heatmap of different inflammatory activities arranged by ANG expression in CGGA301 glioblastoma. (C) Intercorrelation between ANG and seven metagenes in CGGA301 lower-grade glioma. (D) Intercorrelation between ANG and seven metagenes in CGGA301 glioblastoma. LGG, lower grade glioma; GBM, glioblastoma; MUT, mutation; WT, wildtype; CL, classical; ME, mesenchymal; PN, proneural; Codel, codeletion; Noncodel, non-codeletion; Methyl, methylated; Unmethyl, unmethylated; NA, not available; HCK, hemopoietic cell kinase, representing immune activities of the monocyte–macrophage lineage; LCK, lymphocyte-specific kinase, representing T-cell immunity; MHC I, major histocompatibility complex I, representing presentation of intracellular antigens; MHC II, major histocompatibility complex II, representing activities of antigen-presenting cells; IgG, representing B-cell immunity; STAT1, signal transducer and activator of transcription 1, representing interferon signal transduction; IFN, interferon, representing interferon-induction and interferon-response. * indicates p value <0.05, **indicates p value <0.01, **** indicates p value <0.0001.