Table 1.
Baseline demographic and clinical characteristics of the study population
| All (n = 1650) | Males (n = 830) | Females (n = 820) | P | |
|---|---|---|---|---|
| Age, yrs | 52.2 ± 11.3 | 52.3 ± 11.4 | 52.1 ± 11.2 | 0.719 |
| Body mass index, Kg/m2 | 26.9 ± 3.4 | 27.0 ± 3.3 | 26.8 ± 3.5 | 0.232 |
| Current smokers, % | 510 (31.0) | 262 (31.5) | 250 (30.5) | 0.569 |
| Heart rate, bpm | 72.5 ± 9.2 | 72.5 ± 9.3 | 72.6 ± 9.1 | 0.825 |
| Systolic BP, mmHg | 156.0 ± 11.9 | 155.1 ± 11.7 | 156.9 ± 12.1 | 0.002 |
| Diastolic BP, mmHg | 93.5 ± 9.3 | 93.2 ± 9.2 | 93.8 ± 9.3 | 0.187 |
| Mean BP, mmHg | 62.5 ± 10.5 | 61.9 ± 10.4 | 63.1 ± 10.7 | 0.021 |
| Total cholesterol, mg/dl | 207.5 ± 34.1 | 206.9 ± 32.9 | 208.1 ± 35.4 | 0.475 |
| LDL-cholesterol, mg/dl | 124.2 ± 35.3 | 123.6 ± 34.2 | 124.8 ± 36.5 | 0.491 |
| HDL-cholesterol, mg/dl | 49.8 ± 10.9 | 50.1 ± 10.8 | 49.6 ± 11.0 | 0.351 |
| Triglyceride, mg/dl | 112.5 ± 27.3 | 113.3 ± 27.7 | 111.6 ± 26.9 | 0.206 |
| Fasting glucose, mg/dl | 94.7 ± 10.7 | 94.5 ± 10.4 | 95.0 ± 10.1 | 0.322 |
| Insulin, U/L | 12.9 ± 3.6 | 12.5 ± 3.3 | 13.2 ± 3.9 | 0.0001 |
| HOMA | 3.0 + 0.9 | 2.9 ± 0.8 | 3.1 ± 1.0 | 0.0001 |
| Uric Acid, mg/dl | 4.8 ± 1.4 | 4.8 ± 1.3 | 4.9 ± 1.4 | 0.133 |
| Creatinine, mg/dl | 0.96 ± 0.21 | 0.93 ± 0.21 | 0.99 ± 0.21 | 0.0001 |
| e-GFR, mL/min/1.73m2 | 78.6 ± 22.0 | 89.1 ± 19.5 | 67.9 ± 19.0 | 0.0001 |
| hs-CRP, mg/dl | 4.0 ± 0.9 | 3.8 ± 0.8 | 4.1 ± 0.9 | 0.001 |
| MACE, (%) | 424 (2.71) | 184 (2.33) | 240 (3.08) | 0.001 |
| Coronary events, (%) | 250 (1.59) | 108 (1.36) | 142 (1.82) | 0.014 |
| Cerebrovascular events, (%) | 118 (0.75) | 45 (0.57) | 73 (0.93) | 0.006 |
| Overall mortality, (%) | 56 (0.36) | 26 (0.33) | 30 (0.38) | 0.555 |