Skip to main content
. 2023 Nov 1;22:298. doi: 10.1186/s12933-023-02006-z

Table 2.

Univariate Cox regression analysis for incident MACE, coronary and cerebrovascular events, and overall mortality

MACE Coronary events Cerebrovascular events Overall mortality
HR 95% CI P HR 95% CI P HR 95% CI P HR 95% CI P
All
 HOMA, 1 unit 1.486 1.358–1.626 0.000 1.513 1.347–1.700 0.000 1.503 1.272–1.777 0.000 1.324 1.016–1.725 0.038
 Uric acid, mg/dl 1.433 1.349–1.521 0.000 1.499 1.387–1.619 0.000 1.294 1.148–1.458 0.000 1.431 1.216–1.684 0.000
 Sex, females 1.287 1.063–1.559 0.010 1.341 1.044–1.723 0.021 1.446 1.002–2.086 0.049 0.844 0.498–1.429 0.527
 hs-CRP, mg/L 1.283 1.158–1.422 0.000 1.268 1.108–1.451 0.000 1.276 1.049–1.552 0.015 1.362 1.039–1.786 0.025
 SBP, 10 mmHg 1.139 1.056–1.228 0.000 1.227 1.15–1.350 0.000 1.027 0.885–1.191 0.730 0.990 .0795–1.232 0.925
 Age, 10 yrs 1.010 1.002–1.019 0.016 1.017 1.005–1.028 0.003 1.005 0.989–1.021 0.517 0.994 0.972–1.017 0.601
 e-GFR, 10 ml/min/1.7m2 0.921 0.882–0.962 0.000 0.992 0.871–0.975 0.000 0.968 0.893–1.049 0.426 0.823 0.725–0.934 0.002
 Smoking, yes/no 1.185 0.968–1.452 0.101 1.183 0.912–1.534 0.207 1.373 0.947–1.991 0.094 0.890 0.498–1.589 0.694
 Total cholesterol, 10 mg/dl 0.998 0.996–1001 0.286 0.982 0.946–1.018 0.325 0.962 0.912–1.016 0.163 0.977 0.877–1.077 0.590
 LDL-cholesterol, 10 mg/dl 1.001 0.999–1004 0.345 1.014 0.980–1.049 0.416 0.993 0.944–1.044 0.775 1.080 1.008–1.156 0.029
 Triglyceride, 10 mg/dl 1001 0.997–1.004 0.628 0.994 0.950–1.040 0.791 1.037 0.973–1.105 0.261 1.013 0.914–1.123 0.645
 Body mass index, Kg/m2 0.979 0.953–1.008 0.157 1.003 0.967–1.040 0.873 0.948 0.898–1.007 0.066 0.922 0.851–1.097 0.069
 Heart rate, 10 beats/min 1.008 0.997–1.018 0.160 1.076 0.940–1.230 0.288 1.140 0.940–1.384 0.184 1.032 0.777–1.369 0.829
Males
 Uric acid, mg/dl 1.388 1.259–1.531 0.000 1.447 1.275–1.641 0.000 1.207 1.098–1.477 0.025 1.478 1.165–1.876 0.001
 hs-CRP, mg/L 1.325 1.142–1.536 0.000 1.285 1.054–1.566 0.013 1.373 1.028–1.833 0.032 1.386 0.978–1.965 0.067
 HOMA, 1 unit 1.291 1.091–1.527 0.003 1.375 1.104–1.713 0.004 1.176 0.845–1.637 0.337 1.193 0.784–1.817 0.410
 SBP, 10 mmHg 1.151 1.026–1.290 0.016 1.328 1.151–1.533 0.000 1.013 0.799–1.285 0.913 0.766 0.544–1.078 0.126
 Age, 10 yrs 1.007 0.995–1.020 0.265 1.018 1.002–1.035 0.030 0.997 0.973–1.021 0.801 0.985 0.955–1.015 0.320
 Smoking 1.211 0.908–1.614 0.192 1.124 0.754–1.677 0.565 1.893 1.078–3.325 0.026 0.952 0.438–2.071 0.902
 e-GFR, 10 ml/min/1.7m2 0.985 0.918–1.058 0.681 1.003 0.913–1.102 0.949 1.067 0.925–1.230 3.73 0.819 0.687–0.977 0.026
 Total cholesterol, 10 mg/dl 0.996 0.924–1.009 0.123 0.961 0.907–1.019 0.181 0.953 0.874–1.040 0.282 1.003 0.903–1.115 0.951
 LDL-cholesterol, 10 mg/dl 1.006 0.967–1.082 0.757 0.995 0.943–1.049 0.839 0.970 0.895–1.051 0.452 1.105 1.007–1.212 0.034
 Triglyceride, 10 mg/dl 1.027 0.975–1082 0.310 1.008 0.941–1.080 0.819 1.132 0.931–1.242 0.196 0.914 0.795–1.051 0.206
 Body mass index, Kg/m2 0.973 0.930–1.017 0.224 1.009 0.952–1.068 0.774 0.940 0.860–1.207 0.169 0.897 0.798–1008 0.068
 Heart rate, 10 beats/min 1.120 0.963–1.301 0.141 0.997 0.817–1.216 0.975 1.145 1.008–1.311 0.034 1.156 0.796–1.679 0.446
Females
 HOMA, 1 unit 1.552 1.395–1.727 0.000 1.541 1.342–1.770 0.000 1.598 1.319–1.936 0.000 1.480 1.048–2.091 0.026
 Uric acid, 1 mg/dl 1.450 1.341–1.567 0.000 1.517 1.373–1.675 0.000 1.323 1.140–1.535 0.000 1.428 1.130–1.803 0.003
 hs-CRP, 1 mg/L 1.223 1.056–1.415 0.007 1.221 1.010–1.475 0.039 1.162 0.885–1.526 −0.281 1.410 0.914–2.176 0.120
 SBP, 10 mmHg 1.106 1.000–1.224 0.049 1.128 0.992–1.284 0.067 1.008 0.831–1.221 0.938 1.262 0.937–1.700 0.126
 Age, 10 yrs 1.015 1.003–1.026 0.015 1.017 1.002–1.032 0.031 1.013 0.992–1.035 0.229 1.006 0.972–1.042 0.730
 e-GFR, 10 ml/min/1.7m2 0.884 0.822–0.950 0.000 0.885 0.806–0.971 0.010 0.965 0.853–1.093 0.575 0.624 0.464–0.840 0.002
 Smoking, yes/no 1.127 0.861–1.475 0.385 1.204 0.853–1.698 0.291 1.343 0.875–1.325 0.089 0.842 0.351–2.016 0.699
 Total cholesterol, 10 mg/dl 0.993 0.957–1.030 0.698 0.995 0.949–1.044 0.850 0.968 0.904–1.037 0.360 1.046 0.936–1.069 0.430
 LDL-cholesterol, 10 mg/dl 1.022 0.988–1.058 0.211 1.024 0.980–1.071 0.286 1.005 0.943–1.071 0.870 1.055 0.952–1.170 0.304
 Triglyceride, 10 mg/dl 0.989 0.944–1.036 0.631 0.986 0.929–1.047 0.649 0.971 0.890–1.060 0.512 1.048 0.918–1.196 0.491
 Body mass index, Kg/m2 0.985 0.950–1.022 0.421 1.005 0.960–1.052 0.837 0.960 0.897–1.028 0.243 0.943 0.843–1.055 0.308
 Heart rate, 10 beats/min 1.063 0.922–1.225 0.401 1.157 0.964–1.389 0.117 1.163 0.956–1.491 0.125 0.868 0.560–1.346 0.527