. 2023 Nov 1;22:298. doi: 10.1186/s12933-023-02006-z

Table 3.

Multivariate Cox regression analysis for incident MACE, coronary and cerebrovascular events, and overall mortality

	MACE			Coronary events			Cerebrovascular events			Overall mortality
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
All
Uric acid, mg/dl	1.415	1.328–1.508	0.000	1.493	1.375–1.621	0.000	1.256	1.109–1.423	0.000	1.469	1.237–1.745	0.000
HOMA, 1 unit	1.402	1.274–1.542	0.000	1.401	1.239–1.585	0.000	1.469	1.232–1.751	0.000	–	–	–
hs-CRP, mg/L	1.302	1.177–1.441	0.000	1.293	1.132–1476	0.000	1.294	1.066–1.571	0.009	1.324	1.010–1.735	0.042
Systolic BP, 10 mmHg	1.085	1.004–1.172	0.040	1.167	1.057–1.288	0.002	–	–	–	–	–	–
Age, 10 yrs	1.010	1.002–1.019	0.020	1.015	1.004–1.027	0.007	–	–	–	–	–	–
e-GFR, 10 ml/min/1.7m²	–	–	–	–	–	–	–	–	–	0.855	0.755–0.968	0.013
Males
Uric acid, mg/dl	1.372	1.240–1.519	0.000	1.435	1.261–1.633	0.000	1.183	1.086–1.282	0.18	1.388	1.270–1.613	0.000
hs-CRP, mg/L	1.277	1.101–1.480	0.001	–	–	–	1.473	1.082–2.005	0.014	–	–	–
HOMA, 1 unit	1.216	1.029–1.438	0.022	1.270	1.023–1.576	0.030	–	–	–	–	–	–
Systolic BP, 10 mmHg	–	–	–	1.292	1.113–1.500	0.000	–	–	–	–	–	–
Age, 10 years	–	–	–	1.017	1.000–1.034	0.050	–	–	–	–	–	–
Heart rate, 10 beats/min							1.419	1.062–1.896	0.018
e-GFR, 10 ml/min/1.7m²	–	–	–	–	–	–	–	–	–	0.685	0.572–0.821	0.000
Females
HOMA, 1 unit	1.526	1.356–1.517	0.000	1.510	1.294–1.763	0.000	1.554	1.270–1.901	0.000	–	–	–
Uric acid, 1 mg/dl	1.431	1.318–1.553	0.000	1.509	1.360–1.676	0.000	1.273	1.093–1.482	0.002	1.416	1.113–1.800	0.005
hs-CRP, 1 mg/L	1.367	1.182–1.580	0.000	1.401	1.166–1.683	0.000	–	–	–	–	–	–
e-GFR, 10 ml/min/1.7m²	0.915	0.854–0.981	0.012	–	–	–	–	–	–	0.634	0.470–0.854	0.003
Age, 10 years	–	–	–	1.018	1.002–1.033	0.026	–	–	–	–	–	–