Table 3.

Summary of the quality of evidence according to the Grading of Recommendation Assessment, Development, and Evaluation (GRADE)

Patient or population: Adult patients with expected trauma-induced coagulopathy Settings: In-hospital care Intervention: Patients treated with PCC Comparison: Patients treated without PCC

Outcomes No of participants (studies)	Odds ratio	Anticipated absolute effects			Certainty of the evidence (GRADE)	Comments
		Without PCC	With PCC	Difference
Mortality (8 studies, n = 1685)	0.94 [0.60, 1.45]	27.2%	22.4%	−  4.8%	⊕  ⊝  ⊝  ⊝  Very lowa,b	May decrease in-hospital mortality
DVT (6 studies, n = 1497)	1.00 [0.64; 1.55]	5.3%	7.0%	+ 1.3%	⊕  ⊝  ⊝  ⊝  Very Lowa,c,d	May increase DVT

^aDowngraded because the overall risk of bias for observational studies was serious

^bDowngraded because PCC administration was not associated with mortality reduction in the only RCT published

^cDowngraded because of the large confidence intervals

^dDowngraded because the only RCT did not reported a significant increase of the DVT (but an increase of a composite outcome regrouping the occurrence of at least one thromboembolic event)

DVT deep venous thrombosis, PCC prothrombin complex concentrate