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. 2023 Oct 31;14(1):2273567. doi: 10.1080/21505594.2023.2273567

Table 3.

Combination therapy of phage depolymerase and some antibiotics in the treatment of bacterial biofilm.

Depolymerase Origin phage Phage family Bacterium genus Antibiotics Combined outcome Substrate Application
model
Study references
Dep42 SH-KP152226 Podoviridae K. pneumoniae polymyxin synergy K47 capsule In vitro [15]
KPO1K2 associated depolymerase KPO1K2 - K. pneumoniae ciprofloxacin synergy biofilm In vitro [110]
DepoKP36 vB_KpnS_KP36 Siphoviridae K. pneumoniae ciprofloxacin, oxytetracycline, and chloramphenicol synergy K63 capsule Galleria mellonella [13]
Dpo71 IME-AB2 - A. baumannii colistin synergy Biofilm Galleria mellonella [16]
KP34p57 KP34 - K. pneumoniae ciprofloxacin Neutral Biofilm In vitro [111]
DpoMK34 vB_AbaP_PMK34 - A. baumannii Imipenem, amikacin, and colistin Neutral K2 capsule In vitro [14]
TF φAB2 - A. baumannii colistin antagonism exopolysaccharide (EPS) In vitro [112]