Baseline 18F-FDG PET/CT performed before chemoradiation for staging purposes. MIP (a), sagittal (b), and axial 18F-FDG PET/CT images (b, c) revealed hypermetabolic left glottic malignancy (arrows). Additionally, axial PET/CT images of the neck (e–f) showed a few ipsilateral hypermetabolic cervical lymphadenopathies involving II–IV levels (dotted arrows). In follow-up, 18F-FDG PET/CT performed after chemoradiation for response assessment, MIP (g), sagittal (h), and axial PET/CT images (i–l) revealed evidence of complete resolution in the previous local disease. This was, however, complicated by a distant hypermetabolic intramedullary focus occupying the right proximal femur, as evidenced by the MIP image, necessitating further evaluation (curved arrow). 18F-FDG PET/CT, 18-fluorine fludeoxyglucose positron emission tomography/CT; MIP, maximum intensity projection.