Table 1.
Comparison of Clinicopathologic Characteristics (t Test, Pearson Chi-Square, Fisher’s Exact Test) Between Patients With Sarcomatoid and Conventional Urothelial Histology Treated With Radical Cystectomy.
| SUC | CUC | ||
|---|---|---|---|
| Variables | N = 38 | N = 287 | P Value (Pearson χ2, Fischer exact test, t test) |
| Gender | n, % | n, % | |
| Male | 28 (74) | 220 (77) | .686 |
| Female | 10 (26) | 67 (23) | |
| Median age (y, IQR) | 70 (60–76) | 67 (60–76) | .987 |
| Stage at diagnosis | |||
| cT2 | 20 (53) | 162 (56) | .656 |
| cT3/4 | 18 (47) | 125 (44) | |
| Nodal disease (imaging) | 7 (18) | 25 (9) | .078 |
| CIS+ (TURBT) | 11 (29) | 61 (21) | .289 |
| LVI+ (TURBT) | 4 (11) | 36 (13) | .802 |
| Surgical pathology | |||
| pT0N0 | 3 (8) | 71 (25) | .015 |
| pTa/T1/CIS | 3 (8) | 72 (25) | <.001 |
| pT2 | 7 (18) | 45 (16) | .665 |
| pT3/T4 | 25 (66) | 99 (35) | <.001 |
| pTanyN+ | 10 (26) | 58 (20) | .384 |
| Positive margins | 2 (5) | 17 (6) | 1.000 |
| CIS+ | 9 (24) | 61 (21) | .732 |
| LVI+ | 8 (21) | 55 (19) | .782 |
| Recurrence rate | 17 (45) | 81 (28) | .041 |
| Neoadjuvant CT | 17 (45) | 162 (56) | .173 |
| pCR (ypT0N0) | 1/17 (6) | 56/162 (35) | 0.016 |
Abbreviations: CUC = conventional urothelial carcinoma; cT = clinical tumor stage; CT = chemotherapy; CIS = carcinoma in situ; IQR = interquartile range; LVI = lymphovascular invasion; pT = pathologic tumor stage; SUC = sarcomatoid urothelial carcinoma.